Detailed view for Bm1_54530

Basic information

TDR Targets ID: 243909
Brugia malayi, Myotubularin-related family protein
Source Database / ID:  GenBank

pI: 7.2519 | Length (AA): 1486 | MW (Da): 167309 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02141   DENN (AEX-3) domain
PF02893   GRAM domain
PF03456   uDENN domain
PF06602   Myotubularin-like phosphatase domain
PF12335   Myotubularin protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  
GO:0016311   dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 417 3tw8 (A) 4 369 25.00 0 1 0.348446 0.03
34 319 3tw8 (A) 32 303 27.00 0 1 0.326863 0.22
821 1483 1zsq (A) 73 489 30.00 0 1 0.0226642 1.75
1071 1483 1zsq (A) 212 489 38.00 0 0.7 0.0883273 0.96
1203 1486 5c16 (A) 245 513 24.00 0 0.79 0.366617 0.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131105)

Species Accession Gene Product
Brugia malayi Bm1_54530   Myotubularin-related family protein
Caenorhabditis elegans CELE_H28G03.6   Protein MTM-5
Drosophila melanogaster Dmel_CG6939   SET domain binding factor
Echinococcus granulosus EgrG_000857000   myotubularin protein 13
Echinococcus multilocularis EmuJ_000857000   myotubularin protein 13
Homo sapiens ENSG00000100241   SET binding factor 1
Homo sapiens ENSG00000133812   SET binding factor 2
Loa Loa (eye worm) LOAG_04469   hypothetical protein
Mus musculus ENSMUSG00000036529   SET binding factor 1
Mus musculus ENSMUSG00000038371   SET binding factor 2
Schistosoma japonicum Sjp_0043360   Myotubularin-related protein 13, putative
Schistosoma mansoni Smp_158820   myotubularin-related protein
Schmidtea mediterranea mk4.007213.00  
Schmidtea mediterranea mk4.015377.00  
Schmidtea mediterranea mk4.012312.00  
Schmidtea mediterranea mk4.012312.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_54530 (Brugia malayi), Myotubularin-related family protein
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